John goodier supermind1/12/2024 ![]() In addition, I will assay in cell culture the efficiency of the L1 at integrating increasing lengths of exogenous DNA. I don't really know if it's fair to write a critical review just because I expected something completely different. I also will test the ability of wild-type R1, R2, and Tx1L elements to retrotranspose in human cells and will consider their direct application as gene delivery vectors. Being a John's subscriber on YouTube I decided to give it a go because unlike most sci-fi writers he seems to be really into hard science and cosmology. GAL4 binding domain, zinc finger domains). This may be accomplished by replacing the L1 endonuclease domain with endonuclease domains from site-specific retrotransposons of other species, including the R1 element of insects and the Tx1L element from Xenopus, or by linking the L1 endonuclease domain to site-specific binding motifs (eg. This proposal is designed to explore strategies for modifying the L1 retrotransposon to produce a gene delivery vector which can target to specific sequences in the human genome.
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